Surfactant in Clinical Practice Proceedings of an International Symposium Parma, Italy, 4-5 June 1990

Cover of: Surfactant in Clinical Practice |

Published by Harwood Academic Publishers .

Written in English

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  • Paediatric medicine,
  • Pharmacology,
  • Respiratory distress syndrome,
  • Pulmonary & Thoracic Medicine,
  • Respiratory Diseases,
  • Respiratory Therapy,
  • physiology,
  • Medical / Nursing,
  • Health/Fitness,
  • Pulmonary Surfactants,
  • Chemotherapy,
  • Therapeutic use,
  • Congresses,
  • Pulmonary surfactant

Edition Notes

Book details

ContributionsStefano Parmigiani (Editor), Giulio Bevilacqua (Editor), Bengt Robertson (Editor)
The Physical Object
Number of Pages236
ID Numbers
Open LibraryOL9078832M
ISBN 10371865279X
ISBN 109783718652792

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Surfactant Science: Principles and Practice A free eBook linked to the apps in Practical Surfactants And, by popular request, for those who prefer to sit down and read a real hardback book, you can purchase a copy from DEStech Publications. Everything I've learned whilst developing Practical Surfactants and formulating in the real world is brought together in my book.

The future of surfactant formulation practice Preface The target audience for this book is a younger version of myself. I have included all those things I wish I had known years ago. Had I had this book, my life of formulating with surfactants would have been so much more productive.

Since the first edition Surfactant in Clinical Practice book this book was published inthere has been a spectacular development in both basic research on the pulmonary surfactant system and the clinical use of surfactant for treatment of lung diseases hence the addition of the subtitle indicating the expansion of knowledge in the field and the expanded information Cited by: ISBN: OCLC Number: Description: xii, pages: illustrations ; 25 cm: Contents: Ch.

History of surfactant research / M. For the most part, surfactant is administered intratracheally, followed by mechanical ventilation. In recent years, the growing interest in noninvasive ventilation has led to novel approaches of administration. This paper will review these techniques and the associated clinical by: 7.

The update of this clinical practice guideline is based on clinical trials and systematic reviews, and 12 articles investigating surfactant replacement therapy. Methods Used to Assess the Quality and Strength of the Evidence.

AARC Clinical Practice Guideline. Surfactant Replacement Therapy: Brian K Walsh RRT-NPS RPFT FAARC, Brandon Daigle RRT-NPS, Robert M DiBlasi RRT-NPS FAARC, and Ruben D Restrepo MD RRT FAARC We searched the MEDLINE, CINAHL, and Cochrane Library databases for English-languageCited by: Whereas surfactant itself has no effect on ductal contractility, the rapid improvement in Pa o 2 observed after surfactant administration can result in a Surfactant in Clinical Practice book fall in pulmonary vascular resistance, producing an earlier clinical presentation of PDA in preterm infants and in experimental animals.

This finding may explain the observation in. What is Surfactant. Pulmonary surfactant is a complex mixture of lipids and proteins; it is synthesized by alveolar pneumocytes type II.

Phospholipids comprise approximately 90% of pulmonary surfactant, of which almost 80% is phosphatidylcholine, 10% is phosphatidylglycerol, and the remainder is made of small amounts of other phospholipids and neutral lipids including Author: Khalid Altirkawi.

Surfactant administration in preterm infants with NRDS reduces morbidity and mortality. AARC Clinical Practice Guideline. Surfactant replacement therapy: This book is distributed.

Surfactant therapy was provided via the ETT, and whether given prophylactically or as treatment, surfactant reduced mortality and the combined outcome of death or chronic lung disease. 44,45 Surfactant therapy appeared more beneficial when given early in the course of RDS.

46 It became common practice for all very preterm infants to be. "This book is designed to give practical help to those involved with the use of surface active agents (or surfactants). It is intended particularly for new graduate and post-graduate chemists and chemical engineers at the beginning of their industrial careers and for those who, in later life, become involved with surfactants for the first : Hardcover.

AASM Clinical Guideline for the Evaluation, Management, and Long-Term Care of Obstructive Sleep Apnea in Adults () PDF: Palliative Care. NCP Clinical Practice Guidelines for Quality Palliative Care, 4th edition () HTML: Pulmonary Arterial Hypertension.

A systematic review of the seven RCTs that have evaluated the use of prophylactic surfactant therapy compared with selective therapy of infants with established RDS suggests that there are important clinical benefits associated with prophylactic surfactant administration.

42 Prophylactic surfactant therapy leads to a decreased risk of Cited by: Unlabelled: Surfactant therapy has significantly changed clinical practice in neonatology over the last 25 years. Recent trials in infants with respiratory distress syndrome (RDS) have not shown.

Pulmonary surfactant is used as a medication to treat and prevent respiratory distress syndrome in newborn babies. Prevention is generally done in babies born at a gestational age of less than 32 weeks.

It is given by the endotracheal tube. Onset of AHFS/: Monograph. Reprinted from the August issue of R ESPIRATORY C ARE [Respir Care (8)–]. AARC Clinical Practice Guideline Surfactant Replacement Therapy. SRT PROCEDURE: Surfactant replacement therapy in the neonate. Lung surfactants are made from animal lung extract and contain phospholipids.

Natural surfactant is produced by the alveolar cells in the lungs and line mainly the alveoli and small bronchioles, and prevents the alveoli from collapsing.

Lung surfactant makes it easier for oxygen to penetrate the lung surface lining and move into the blood. Surfactant-associated proteins, particularly SP-B, appear to be essential in binding, stabilizing, spreading, and recycling phospholipids on the alveolar surfaces.

It has been recently discovered that some infants who develop fatal RDS have a genetic deficiency or a. Clinical indications. Surfactant replacement therapy should be considered in: neonates with clinical and radiographic evidence of RDS; neonates at risk of developing RDS (e.g.

40%; Surfactant replacement therapy may be considered in. The first objective of investigators is to assess the safety of surfactant nebulization in this clinical situation, and to find out whether treatment with aerosolized surfactant would reduce the need for mechanical ventilation.

And other aim suggest that aerosolized dates compared with dates of INSURE (intubation-surfactant-extubation) and. Summary Pulmonary surfactant is a complex mixture of specific lipids, proteins and carbohydrates, which is produced in the lungs by type II alveolar epithelial cells.

The mixture is surface active and acts to decrease surface tension at the air–liquid interface of the alveoli. The presence of such molecules with surface activity had been suspected since the early s Cited by: 4. This article starts with a brief account of the history of research on pulmonary surfactant.

We will then discuss the morphological aspects and composition of the pulmonary surfactant system. We describe the hydrophilic surfactant proteins A and D and the hydrophobic surfactant proteins B and C, with focus on the crucial roles of these proteins in the dynamics, Cited by: Lung Surfactants: Basic Science and Clinical Applications - CRC Press Book Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease.

Surfactants – classification, features and applications Surfactants – classification, features and applications N. Denkov and S. Tcholakova Department of Chemical Engineering, “Surfactant mixtures for control of bubble surface mobility in foam studies”, Langmuir 24 () Etiology of surfactant inactivation or dysfunction: pulmonary hemorrhage, sepsis, pneumonia, meconium aspiration, and post surfactant slump.

Surfactant replacement therapy for RDS - Early rescue therapy should be practiced: First dose needs to be given as soon as diagnosis of RDS is made. RDS in a premature infant is defined as respiratory distress requiring more than 30%. Pulmonary surfactants and their role in pathophysiology of lung disorders Aparna Akella & Shripad B Deshpande* Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, VaranasiIndia Surfactant is an agent that decreases the surface tension between two media.

The surface tension between gaseous. Surfactants are an extraordinary class of versatile amphiphilic compounds which have a spatially distinctive polar hydrophilic head and non-polar hydrophobic tail group.

Due to its amphiphilic nature and unique feature of decreasing the interfacial tension, the surfactant is widely used in every walk of life such as individual care products, domestic cleaners, pharmaceuticals, oil Author: Ashok Kumar Janakiraman, Muhammad Suhail, Arshad Khan, Abid Naeem, Syed Faisal Badshah, Ommega Inter.

New. Keep up with current practice guidelines and policies with the latest, most up-to-date edition of this clinical reference classic. This evidence-based decision-making tool for managing common pediatric conditions has been revised and updated forwith the latest clinical practice guidelines for more than 30 conditions, plus every AAP policy statement, clinical report, and.

Developed by a distinguished editorial board, the Perinatal Continuing Education Program (PCEP) is a comprehensive, self-paced education program in four volumes.

This popular resource features step-by-step skill instruction, and practice-focused exercises covering maternal and fetal evaluaton and immediate newborn care. The PCEP workbooks feature leading-edge Author: John Kattwinkel, Robert J.

Boyle, Christian A. Chisholm, Susan B. Clarke. When exogenous surfactant is administered in clinical practice, its distribution is not ideal, but is often good enough because of the biophysical properties of surfactant and the small amount that is needed regionally in the lung for a treatment response (Jobe ).

Surfactant replacement therapy has been the mainstay of treatment for preterm infants with respiratory distress syndrome for more than twenty years. For the most part, surfactant is administered intratracheally, followed by mechanical ventilation.

In recent years, the growing interest in noninvasive ventilation has led to novel approaches of by: 7. Surfactant therapy is the medical administration of exogenous surfactant.

Surfactants used in this manner are typically instilled directly into the trachea. When a baby comes out of the womb and the lungs are not developed yet, they require administration of surfactant in order to process oxygen and survive.

Pediatric respiratory failure develops when the rate of gas exchange between the atmosphere and blood is unable to match the body's metabolic demands. It is diagnosed when the patient’s respiratory system loses the ability to provide sufficient oxygen to the blood, and hypoxemia develops, or when the patient is unable to adequately ventilate.

Surfactant-Based Separations Science and Technology Edited by John F. Scamehorn and Jeffrey H. Harwell. American Chemical Society. ACS Symposium Series. Because they are biodegradable and work well in low energy separations, surfactants are an active area of interest in separations science.

Experimental studies with premature animals demonstrated that surfactant given via the trachea could improve lung function, 8,9 and the first report of successful surfactant treatment of RDS was published in by Fujiwara et al. 10 Surfactants were licensed for general clinical use in – by the Food and Drug Administration (FDA).

Subsequent technological. CUROSURF (poractant alfa) is a sterile, non-pyrogenic pulmonary surfactant intended for intratracheal use only. CUROSURF is an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids) and 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B and SP-C).

A clinical trial involving children with respiratory syncytial virus showed improved lung function and shorter hospital stays in those receiving exogenous surfactant compared to non–surfactant-treated control subjects.

It is difficult, however, to separate the biophysical aspects of the improved lung function observed from the. The straight chain is a saturated /unsaturated CC18 aliphatic group. The water solubility potential of the surfactant is determined by the presence of double bonds.

( science and practice of pharmacy) (b) Cationic Surfactants: In solution, the head of the cationic surfactant is positively charged. Surfactants today you have probably eaten some, or rubbed others on your body. Plants, animals (including you) and microorganisms make them, and many everyday products (e.g.

detergents, cosmetics, foodstuffs) contain them. Surfactant molecules have one part which is soluble in water and another which is not. This gives surfactant molecules two valuable.

more surfactant leads to formation of more micelles increasing the micellar concentration or the micellar growth while the surfactant monomers in the system remain more or less unchanged.

The result is a decrease in the average distance between the micelles and hence an increase in inter-micellar repulsion. Long recognized as the authoritative leader in the field, Creasy and Resnik's Maternal-Fetal Medicine, 8th Edition, continues to provide the latest evidence-based guidelines for obstetric and neonatal management, helping you minimize complications and offer patients the best possible care.

Written by renowned experts in obstetrics, gynecology, and perinatology, 5/5(1).The book has been out of print for some time. Owing to pressure of other work, Professor P. H. Elworthy and Dr C. B. Macfarlane were unable to undertake the work of revision but while working together on an undergraduate textbook the present authors decided to set to work, realizing both the impossibility of producing a comprehensive textbook.

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